![]() ![]() Changes in ongoing EEG oscillations may be related to the impaired task performance that has often been reported after drug intake.Īlcohol (ethanol), cannabis and ecstasy are the most commonly used psychoactive substances for recreational purpose in Western society. The present findings indicate that the combined intake of MDMA and THC, but not of MDMA and alcohol, affects ongoing EEG oscillations differently than the sum of either one drug alone. For the lower-2-alpha band, the intake of MDMA or THC alone did not significantly affect power, but the intake of combined MDMA and THC significantly decreased lower-2-alpha power. Significant MDMA × THC effects for theta and lower-1-alpha power indicated that the power attenuation after the combined intake of MDMA and THC was less than the sum of each drug alone. No interaction between alcohol and MDMA was found. Theta and alpha power increased after alcohol intake compared to placebo and reduced after MDMA intake. Before and after drug administration, electroencephalography was recorded during an eyes closed resting state. In two separate experiments, 16 volunteers received four different drug conditions: (1) MDMA (100 mg) (2) alcohol clamp (blood alcohol concentration = 0.6‰) or THC (inhalation of 4, 6 and 6 mg, interval of 1.5 h) (3) MDMA in combination with alcohol or THC and (4) placebo. The aim of the present study was to investigate whether co-administration of alcohol or THC with MDMA differentially affects ongoing electroencephalogram (EEG) oscillations compared to the administration of each drug alone. Typical users of 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”) are polydrug users, combining MDMA with alcohol or cannabis. ![]()
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